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Electrophoresis separates proteins based on their physical properties, and the subsets of these proteins are used in interpreting the results. what does no apparent monoclonal protein on serum electrophoresis mean. Dimopoulos M, Kyle R, Fermand JP, et al. Pathol Biol (Paris). Proteins play many important roles, including providing energy for the body, rebuilding muscles, and supporting the immune system. Protein Electrophoresis questions. All rights reserved. Further separation of protein subtypes is achieved by staining with an immunologically active agent, which results in immunofluorescence and immunofixation. 95:2126-33. Measuring M-Protein SPEP, UPEP Tests | Int'l Myeloma Fdn Portland (ME): Maine Health; c2019. Once the serum samples are run on the analyzer, a technologist compares the curves with patients previous results and ensures the fractions are appropriately delineated. Both of the following criteria must be met: In healthy individuals, plasma cellsproduce proteins called polyclonal immunoglobulins. These are a collection of antibodies that protect the body against all kinds of different invading viruses, bacteria or other infectious agents (antigens). Some immunoglobulins can be abnormal and may be due to cancer. Please confirm that you would like to log out of Medscape. Evidence of end-organ damage as defined by the CRAB criteria. Levels of albumin are increased in patients with a relative reduction in serum water (e.g., dehydration). [14], Mass spectrometry is sometimes employed in place of immunofixation because of the latters limitations, such as in the detection of low-level disease. There is less than 10 percent plasma cell involvement on bone marrow biopsy. NGS can identify mutations present in the genes of the myeloma cells. [Internet]. MGUS is usually detected by chance when you have a blood test for another condition. This article provides a comprehensive review of serum protein electrophoresis, including a discussion of how the examination is performed, what it measures, and when it is indicated. Mayo Clinic, Rochester, Minn. April 26, 2019. Alexandria (VA): American Society of Clinical Oncology; 20052019. M Protein (Myeloma Protein): Definition, Test, and Levels - WebMD An accurate diagnosis is one of the most important aspects of a persons medical care. Pruthi RK (expert opinion).
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what does no apparent monoclonal protein on serum electrophoresis mean